TEP1

Telomerase-associated protein 1
Identifiers
Symbols	TEP1 ; TLP1; TP1; TROVE1; VAULT2; p240
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5157
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TEP1 205727 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Telomerase-associated protein 1, also known as TEP1, is a human gene.

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.

Further reading

• Joly EC, Tremblay E, Tanguay RM; et al. (1995). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". J. Cell. Sci. 107 ( Pt 10): 2851–9. PMID 7876352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrington L, McPhail T, Mar V; et al. (1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. PMID 9020079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrington L, Zhou W, McPhail T; et al. (1998). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes Dev. 11 (23): 3109–15. PMID 9389643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito T, Matsuda Y, Suzuki T; et al. (1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. PMID 9403057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Zhao L, Yang Z; et al. (1999). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". J. Biol. Chem. 273 (50): 33436–42. PMID 9837921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kickhoefer VA, Stephen AG, Harrington L; et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Cao Y, Berndt MC; et al. (2000). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koyanagi Y, Kobayashi D, Yajima T; et al. (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Res. 20 (2A): 773–8. PMID 10810353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beattie TL, Zhou W, Robinson MO, Harrington L (2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding". Mol. Biol. Cell. 11 (10): 3329–40. PMID 11029039.CS1 maint: Multiple names: authors list (link)
• Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.CS1 maint: Multiple names: authors list (link)
• Chang JT, Chen YL, Yang HT; et al. (2002). "Differential regulation of telomerase activity by six telomerase subunits". Eur. J. Biochem. 269 (14): 3442–50. PMID 12135483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou JH, Zhang HM, Chen Q; et al. (2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World J. Gastroenterol. 9 (8): 1808–14. PMID 12918126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li C, Wu MY, Liang YR, Wu XY (2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World J. Gastroenterol. 9 (11): 2395–9. PMID 14606063.CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)