THBS4

Thrombospondin 4
Identifiers
Symbols	THBS4 ; TSP4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20691
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE THBS4 204776 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thrombospondin 4, also known as THBS4, is a human gene.

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.

Further reading

• Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth". J. Cell Biol. 131 (4): 1083–94. PMID 7490284.
• Lawler J, McHenry K, Duquette M, Derick L (1995). "Characterization of human thrombospondin-4". J. Biol. Chem. 270 (6): 2809–14. PMID 7852353.CS1 maint: Multiple names: authors list (link)
• Lawler J, Duquette M, Urry L; et al. (1993). "The evolution of the thrombospondin gene family". J. Mol. Evol. 36 (6): 509–16. PMID 8350346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lawler J, Duquette M, Whittaker CA; et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family". J. Cell Biol. 120 (4): 1059–67. PMID 8432726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Newton G, Weremowicz S, Morton CC; et al. (2000). "The thrombospondin-4 gene". Mamm. Genome. 10 (10): 1010–6. PMID 10501972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carron JA, Hiscott P, Hagan S; et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. PMID 11137453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo J, Dunn T, Ewing C; et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation". Biochem. Biophys. Res. Commun. 324 (2): 673–8. doi:10.1016/j.bbrc.2004.09.107. PMID 15474480.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Doorn R, Zoutman WH, Dijkman R; et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stenina OI, Ustinov V, Krukovets I; et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites". FASEB J. 19 (13): 1893–5. doi:10.1096/fj.05-3712fje. PMID 16148025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2". J. Biol. Chem. 280 (50): 41229–35. doi:10.1074/jbc.M504696200. PMID 16246837.
• Cui J, Randell E, Renouf J; et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population". Am. Heart J. 152 (3): 543.e1–5. doi:10.1016/j.ahj.2006.06.002. PMID 16923428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cáceres M, Suwyn C, Maddox M; et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution". Cereb. Cortex. 17 (10): 2312–21. doi:10.1093/cercor/bhl140. PMID 17182969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)