TIAL1

TIA1 cytotoxic granule-associated RNA binding protein-like 1
File:PBB Protein TIAL1 image.jpg PDB rendering based on 1x4g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x4g​, 2cqi​, 2dgo​, 2dh7​
Identifiers
Symbols	TIAL1 ; MGC33401; TCBP; TIAR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 87796
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TIAL1 202405 at tn.png
File:PBB GE TIAL1 202406 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TIA1 cytotoxic granule-associated RNA binding protein-like 1, also known as TIAL1, is a human gene.

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.

Further reading

• Kawakami A, Tian Q, Duan X; et al. (1992). "Identification and functional characterization of a TIA-1-related nucleolysin". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8681–5. PMID 1326761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taupin JL, Tian Q, Kedersha N; et al. (1995). "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1629–33. PMID 7533298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dember LM, Kim ND, Liu KQ, Anderson P (1996). "Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities". J. Biol. Chem. 271 (5): 2783–8. PMID 8576255.CS1 maint: Multiple names: authors list (link)
• Doi T, Minami T, Itoh M; et al. (1997). "An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene". Biochem. Biophys. Res. Commun. 235 (3): 625–30. doi:10.1006/bbrc.1997.6817. PMID 9207209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin K, Li W, Nagayama T; et al. (2000). "Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury". J. Neurosci. Res. 59 (6): 767–74. PMID 10700014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Guiner C, Lejeune F, Galiana D; et al. (2001). "TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs". J. Biol. Chem. 276 (44): 40638–46. doi:10.1074/jbc.M105642200. PMID 11514562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iseni F, Garcin D, Nishio M; et al. (2002). "Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis". EMBO J. 21 (19): 5141–50. PMID 12356730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Li Y, Kedersha N; et al. (2002). "Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication". J. Virol. 76 (23): 11989–2000. PMID 12414941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu Q, Cok SJ, Zeng C, Morrison AR (2003). "Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR)". J. Biol. Chem. 278 (3): 1579–84. doi:10.1074/jbc.M203526200. PMID 12426321.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Guiner C, Gesnel MC, Breathnach R (2003). "TIA-1 or TIAR is required for DT40 cell viability". J. Biol. Chem. 278 (12): 10465–76. doi:10.1074/jbc.M212378200. PMID 12533540.CS1 maint: Multiple names: authors list (link)
• Cok SJ, Acton SJ, Morrison AR (2003). "The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U.". J. Biol. Chem. 278 (38): 36157–62. doi:10.1074/jbc.M302547200. PMID 12855701.CS1 maint: Multiple names: authors list (link)
• Zhu H, Hasman RA, Young KM; et al. (2003). "U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA". Mol. Cell. Biol. 23 (17): 5959–71. PMID 12917321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shukla S, Dirksen WP, Joyce KM; et al. (2004). "TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1". J. Biol. Chem. 279 (14): 13668–76. doi:10.1074/jbc.M314138200. PMID 14736875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Esclatine A, Taddeo B, Roizman B (2004). "Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs". J. Virol. 78 (16): 8582–92. doi:10.1128/JVI.78.16.8582-8592.2004. PMID 15280467.CS1 maint: Multiple names: authors list (link)
• Hua Y, Zhou J (2004). "Survival motor neuron protein facilitates assembly of stress granules". FEBS Lett. 572 (1–3): 69–74. doi:10.1016/j.febslet.2004.07.010. PMID 15304326.
• Suswam EA, Nabors LB, Huang Y; et al. (2005). "IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. 113 (6): 911–9. doi:10.1002/ijc.20675. PMID 15514971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suswam EA, Li YY, Mahtani H, King PH (2005). "Novel DNA-binding properties of the RNA-binding protein TIAR". Nucleic Acids Res. 33 (14): 4507–18. doi:10.1093/nar/gki763. PMID 16091628.CS1 maint: Multiple names: authors list (link)