TLE1

Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
File:PBB Protein TLE1 image.jpg PDB rendering based on 1gxr.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gxr​, 2ce8​, 2ce9​
Identifiers
Symbols	TLE1 ; ESG; ESG1; GRG1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21058
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TLE1 203221 at tn.png
File:PBB GE TLE1 203220 s at tn.png
File:PBB GE TLE1 203222 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila), also known as TLE1, is a human gene.

Further reading

• Eastman Q, Grosschedl R (1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Curr. Opin. Cell Biol. 11 (2): 233–40. PMID 10209158.
• Stifani S, Blaumueller CM, Redhead NJ; et al. (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nat. Genet. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyasaka H, Choudhury BK, Hou EW, Li SS (1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". Eur. J. Biochem. 216 (1): 343–52. PMID 8365415.CS1 maint: Multiple names: authors list (link)
• Grbavec D, Stifani S (1996). "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif". Biochem. Biophys. Res. Commun. 223 (3): 701–5. doi:10.1006/bbrc.1996.0959. PMID 8687460.
• Husain J, Lo R, Grbavec D, Stifani S (1996). "Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions". Biochem. J. 317 ( Pt 2): 523–31. PMID 8713081.CS1 maint: Multiple names: authors list (link)
• Liu Y, Dehni G, Purcell KJ; et al. (1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palaparti A, Baratz A, Stifani S (1997). "The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3". J. Biol. Chem. 272 (42): 26604–10. PMID 9334241.CS1 maint: Multiple names: authors list (link)
• Levanon D, Goldstein RE, Bernstein Y; et al. (1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11590–5. PMID 9751710.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grbavec D, Lo R, Liu Y; et al. (1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 ( Pt 1): 13–7. PMID 9854018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grbavec D, Lo R, Liu Y, Stifani S (1999). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. 258 (2): 339–49. PMID 9874198.CS1 maint: Multiple names: authors list (link)
• Ren B, Chee KJ, Kim TH, Maniatis T (1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins". Genes Dev. 13 (1): 125–37. PMID 9887105.CS1 maint: Multiple names: authors list (link)
• Tetsuka T, Uranishi H, Imai H; et al. (2000). "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats". J. Biol. Chem. 275 (6): 4383–90. PMID 10660609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang JC, Waltner-Law M, Yamada K; et al. (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932.CS1 maint: Multiple names: authors list (link)
• Gao X, Chandra T, Gratton MO; et al. (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMID 11551980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dasen JS, Barbera JP, Herman TS; et al. (2001). "Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis". Genes Dev. 15 (23): 3193–207. doi:10.1101/gad.932601. PMID 11731482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Liu F, Liu Y, Li D; et al. (2003). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Mol. Cell. Biochem. 232 (1–2): 163–7. PMID 12030375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pickles LM, Roe SM, Hemingway EJ; et al. (2003). "Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor". Structure. 10 (6): 751–61. PMID 12057191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)