TM4SF1

Transmembrane 4 L six family member 1
Identifiers
Symbols	TM4SF1 ; H-L6; L6; M3S1; TAAL6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7409
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TM4SF1 209386 at tn.png
File:PBB GE TM4SF1 209387 s at tn.png
File:PBB GE TM4SF1 215034 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transmembrane 4 L six family member 1, also known as TM4SF1, is a human gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
• Marken JS, Schieven GL, Hellström I; et al. (1992). "Cloning and expression of the tumor-associated antigen L6". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3503–7. PMID 1565644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marken JS, Bajorath J, Edwards CP; et al. (1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". J. Biol. Chem. 269 (10): 7397–401. PMID 7510285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Virtaneva KI, Emi N, Marken JS; et al. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–34. PMID 8168850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borrell-Pagès M, Fernández-Larrea J, Borroto A; et al. (2001). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Mol. Biol. Cell. 11 (12): 4217–25. PMID 11102519.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Storim J, Friedl P, Schaefer BM; et al. (2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Exp. Cell Res. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaneko R, Tsuji N, Kamagata C; et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". Am. J. Gastroenterol. 96 (12): 3457–8. PMID 11774983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao YR, Shih JY, Wen WC; et al. (2004). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clin. Cancer Res. 9 (7): 2807–16. PMID 12855661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang YW, Chen SC, Cheng EC; et al. (2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". Int. J. Cancer. 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)