TNFSF12

Tumor necrosis factor (ligand) superfamily, member 12
Identifiers
Symbols	TNFSF12 ; APO3L; DR3LG; MGC129581; MGC20669; TWEAK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7979
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tumor necrosis factor (ligand) superfamily, member 12, also known as TNFSF12, is a human gene.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.

Further reading

• Wiley SR, Winkles JA (2004). "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor". Cytokine Growth Factor Rev. 14 (3–4): 241–9. PMID 12787562.
• Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity". Front. Biosci. 9: 2273–84. PMID 15353286.CS1 maint: Multiple names: authors list (link)
• Chicheportiche Y, Bourdon PR, Xu H; et al. (1998). "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". J. Biol. Chem. 272 (51): 32401–10. PMID 9405449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marsters SA, Sheridan JP, Pitti RM; et al. (1998). "Identification of a ligand for the death-domain-containing receptor Apo3". Curr. Biol. 8 (9): 525–8. PMID 9560343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lynch CN, Wang YC, Lund JK; et al. (1999). "TWEAK induces angiogenesis and proliferation of endothelial cells". J. Biol. Chem. 274 (13): 8455–9. PMID 10085077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaplan MJ, Ray D, Mo RR; et al. (2000). "TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages". J. Immunol. 164 (6): 2897–904. PMID 10706675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaptein A, Jansen M, Dilaver G; et al. (2000). "Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)". FEBS Lett. 485 (2–3): 135–41. PMID 11094155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiley SR, Cassiano L, Lofton T; et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis". Immunity. 15 (5): 837–46. PMID 11728344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Ishidoh K, Kayagaki N; et al. (2002). "Multiple pathways of TWEAK-induced cell death". J. Immunol. 168 (2): 734–43. PMID 11777967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jakubowski A, Browning B, Lukashev M; et al. (2002). "Dual role for TWEAK in angiogenic regulation". J. Cell. Sci. 115 (Pt 2): 267–74. PMID 11839778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaplan MJ, Lewis EE, Shelden EA; et al. (2003). "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells". J. Immunol. 169 (10): 6020–9. PMID 12421989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada N, Nakayama M, Nakano H; et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 299 (3): 488–93. PMID 12445828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Ishidoh K, Kojima Y; et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death". J. Immunol. 170 (1): 341–8. PMID 12496418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian XL, Kadaba R, You SA; et al. (2004). "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome". Nature. 427 (6975): 640–5. doi:10.1038/nature02320. PMID 14961121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim SH, Kang YJ, Kim WJ; et al. (2004). "TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages". Circ. J. 68 (4): 396–9. PMID 15056843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin L, Nakao A, Nakayama M; et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)