TOP3A
| Topoisomerase (DNA) III alpha | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | TOP3A ; TOP3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3394 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TOP3A 204946 s at tn.png | |||||||||||
| File:PBB GE TOP3A 214300 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Topoisomerase (DNA) III alpha, also known as TOP3A, is a human gene.[1]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.[1]
References
Further reading
- Hanai R, Caron PR, Wang JC (1996). "Human TOP3: a single-copy gene encoding DNA topoisomerase III". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3653–7. PMID 8622991.
- Fritz E, Elsea SH, Patel PI, Meyn MS (1997). "Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4538–42. PMID 9114025.
- Elsea SH, Fritz E, Schoener-Scott R; et al. (1998). "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity". Am. J. Med. Genet. 75 (1): 104–8. PMID 9450867.
- Kim JC, Yoon JB, Koo HS, Chung IK (1998). "Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene". J. Biol. Chem. 273 (40): 26130–7. PMID 9748294.
- Goulaouic H, Roulon T, Flamand O; et al. (1999). "Purification and characterization of human DNA topoisomerase IIIalpha". Nucleic Acids Res. 27 (12): 2443–50. PMID 10352172.
- Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Res. 28 (7): 1647–55. PMID 10710432.
- Wu L, Davies SL, North PS; et al. (2000). "The Bloom's syndrome gene product interacts with topoisomerase III". J. Biol. Chem. 275 (13): 9636–44. PMID 10734115.
- Lin CW, Darzynkiewicz Z, Li X; et al. (2000). "Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes". Exp. Cell Res. 256 (1): 225–36. doi:10.1006/excr.1999.4778. PMID 10739669.
- Brosh RM, Li JL, Kenny MK; et al. (2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. 275 (31): 23500–8. doi:10.1074/jbc.M001557200. PMID 10825162.
- Lodge AJ, Anderson JJ, Ng SW; et al. (2000). "Expression of topoisomerase IIIalpha in normal and neoplastic tissues determined by immunohistochemistry using a novel monoclonal antibody". Br. J. Cancer. 83 (4): 498–505. doi:10.1054/bjoc.2000.1293. PMID 10945498.
- Hu P, Beresten SF, van Brabant AJ; et al. (2001). "Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability". Hum. Mol. Genet. 10 (12): 1287–98. PMID 11406610.
- Freire R, d'Adda Di Fagagna F, Wu L; et al. (2001). "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha". Nucleic Acids Res. 29 (15): 3172–80. PMID 11470874.
- Bi W, Yan J, Stankiewicz P; et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMID 11997338.
- Wang Y, Lyu YL, Wang JC (2002). "Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12114–9. doi:10.1073/pnas.192449499. PMID 12209014.
- Wu L, Hickson ID (2002). "The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha". Nucleic Acids Res. 30 (22): 4823–9. PMID 12433984.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Meetei AR, de Winter JP, Medhurst AL; et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
- Jiao R, Bachrati CZ, Pedrazzi G; et al. (2004). "Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1". Mol. Cell. Biol. 24 (11): 4710–9. doi:10.1128/MCB.24.11.4710-4719.2004. PMID 15143166.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Yin J, Sobeck A, Xu C; et al. (2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity". EMBO J. 24 (7): 1465–76. doi:10.1038/sj.emboj.7600622. PMID 15775963.
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