TOPORS

Topoisomerase I binding, arginine/serine-rich
Identifiers
Symbols	TOPORS ; LUN; TP53BPL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4237
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TOPORS 204071 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Topoisomerase I binding, arginine/serine-rich, also known as TOPORS, is a human gene.

Further reading

• Haluska P, Saleem A, Rasheed Z; et al. (1999). "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein". Nucleic Acids Res. 27 (12): 2538–44. PMID 10352183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou R, Wen H, Ao SZ (1999). "Identification of a novel gene encoding a p53-associated protein". Gene. 235 (1–2): 93–101. PMID 10415337.CS1 maint: Multiple names: authors list (link)
• Souto-Carneiro MM, Krenn V, Hermann R; et al. (2001). "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Res. 2 (4): 303–14. PMID 11056671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chu D, Kakazu N, Gorrin-Rivas MJ; et al. (2001). "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence". J. Biol. Chem. 276 (17): 14004–13. doi:10.1074/jbc.M010262200. PMID 11278651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weger S, Hammer E, Heilbronn R (2002). "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression". J. Gen. Virol. 83 (Pt 3): 511–6. PMID 11842245.CS1 maint: Multiple names: authors list (link)
• Rasheed ZA, Saleem A, Ravee Y; et al. (2002). "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies". Exp. Cell Res. 277 (2): 152–60. PMID 12083797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imabayashi H, Mori T, Gojo S; et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. PMID 12878157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weger S, Hammer E, Engstler M (2003). "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation". Exp. Cell Res. 290 (1): 13–27. PMID 14516784.CS1 maint: Multiple names: authors list (link)
• Saleem A, Dutta J, Malegaonkar D; et al. (2004). "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor". Oncogene. 23 (31): 5293–300. doi:10.1038/sj.onc.1207700. PMID 15107820.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajendra R, Malegaonkar D, Pungaliya P; et al. (2004). "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53". J. Biol. Chem. 279 (35): 36440–4. doi:10.1074/jbc.C400300200. PMID 15247280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oyanagi H, Takenaka K, Ishikawa S; et al. (2005). "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer". Lung Cancer. 46 (1): 21–8. doi:10.1016/j.lungcan.2004.03.009. PMID 15364129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flatten K, Dai NT, Vroman BT; et al. (2005). "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons". J. Biol. Chem. 280 (14): 14349–55. doi:10.1074/jbc.M411890200. PMID 15699047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin L, Ozaki T, Takada Y; et al. (2005). "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene. 24 (21): 3385–96. doi:10.1038/sj.onc.1208554. PMID 15735665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weger S, Hammer E, Heilbronn R (2005). "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo". FEBS Lett. 579 (22): 5007–12. doi:10.1016/j.febslet.2005.07.088. PMID 16122737.CS1 maint: Multiple names: authors list (link)
• Papaioannou M, Chakarova CF, Prescott DC; et al. (2006). "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p". Hum. Genet. 118 (3–4): 501–3. doi:10.1007/s00439-005-0063-3. PMID 16189705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)