TRIM63

Tripartite motif-containing 63
File:PBB Protein TRIM63 image.jpg PDB rendering based on 2d8u.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d8u​
Identifiers
Symbols	TRIM63 ; FLJ32380; IRF; MURF1; MURF2; RNF28; SMRZ
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41878
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TRIM63 gnf1h00833 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tripartite motif-containing 63, also known as TRIM63, is a human gene.

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

Further reading

• Centner T, Yano J, Kimura E; et al. (2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J. Mol. Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai KS, Liew CC (2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J. Biol. Chem. 276 (26): 23992–9. doi:10.1074/jbc.M011208200. PMID 11283016.
• Bodine SC, Latres E, Baumhueter S; et al. (2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science. 294 (5547): 1704–8. doi:10.1126/science.1065874. PMID 11679633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McElhinny AS, Kakinuma K, Sorimachi H; et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMID 11927605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Ray S; et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pizon V, Iakovenko A, Van Der Ven PF; et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein". J. Cell. Sci. 115 (Pt 23): 4469–82. PMID 12414993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kedar V, McDonough H, Arya R; et al. (2005). "Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.". Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18135–40. doi:10.1073/pnas.0404341102. PMID 15601779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462.CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Doucet M, Russell AP, Léger B; et al. (2007). "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 176 (3): 261–9. doi:10.1164/rccm.200605-704OC. PMID 17478621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)