TXK (gene)

TXK tyrosine kinase
File:PBB Protein TXK image.jpg PDB rendering based on 2dm0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dm0​
Identifiers
Symbols	TXK ; BTKL; MGC22473; PSCTK5; PTK4; RLK; TKL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2497
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TXK 206828 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TXK tyrosine kinase, also known as TXK, is a human gene.

Further reading

• Suzuki N, Nara K, Suzuki T (2006). "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease". Clinical medicine & research. 4 (2): 147–51. PMID 16809408.CS1 maint: Multiple names: authors list (link)
• Spritz RA, Strunk KM, Lee ST; et al. (1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haire RN, Ohta Y, Lewis JE; et al. (1994). "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum. Mol. Genet. 3 (6): 897–901. PMID 7951233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohta Y, Haire RN, Amemiya CT; et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wardenburg JB, Fu C, Jackman JK; et al. (1996). "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function". J. Biol. Chem. 271 (33): 19641–4. PMID 8702662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raab M, da Silva AJ, Findell PR, Rudd CE (1997). "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2". Immunity. 6 (2): 155–64. PMID 9047237.CS1 maint: Multiple names: authors list (link)
• Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun. 252 (1): 14–9. doi:10.1006/bbrc.1998.9559. PMID 9813138.CS1 maint: Multiple names: authors list (link)
• Rajagopal K, Sommers CL, Decker DC; et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657–68. PMID 10587356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells". J. Biol. Chem. 275 (6): 3835–40. PMID 10660534.CS1 maint: Multiple names: authors list (link)
• Chamorro M, Czar MJ, Debnath J; et al. (2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk". BMC Immunol. 2: 3. PMID 11353545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeba Y, Nagafuchi H, Takeno M; et al. (2002). "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription". J. Immunol. 168 (5): 2365–70. PMID 11859127.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashiwakura J, Suzuki N, Takeno M; et al. (2002). "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site". Biol. Pharm. Bull. 25 (6): 718–21. PMID 12081135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rafalska I, Zhang Z, Benderska N; et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)