TXNIP

Thioredoxin interacting protein
Identifiers
Symbols	TXNIP ; EST01027; HHCPA78; THIF; VDUP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38186
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TXNIP 201010 s at tn.png
File:PBB GE TXNIP 201008 s at tn.png
File:PBB GE TXNIP 201009 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thioredoxin interacting protein, also known as TXNIP, is a human gene.

Further reading

• Chen KS, DeLuca HF (1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochim. Biophys. Acta. 1219 (1): 26–32. PMID 8086474.
• Nishiyama A, Matsui M, Iwata S; et al. (1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". J. Biol. Chem. 274 (31): 21645–50. PMID 10419473.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig DL, Kotanides H, Le T; et al. (2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene". Gene. 269 (1–2): 103–12. PMID 11376942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bodnar JS, Chatterjee A, Castellani LW; et al. (2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1". Nat. Genet. 30 (1): 110–6. doi:10.1038/ng811. PMID 11753387.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joguchi A, Otsuka I, Minagawa S; et al. (2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat". Biochem. Biophys. Res. Commun. 293 (1): 293–7. doi:10.1016/S0006-291X(02)00208-5. PMID 12054598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butler LM, Zhou X, Xu WS; et al. (2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11700–5. doi:10.1073/pnas.182372299. PMID 12189205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schulze PC, De Keulenaer GW, Yoshioka J; et al. (2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin". Circ. Res. 91 (8): 689–95. PMID 12386145.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han SH, Jeon JH, Ju HR; et al. (2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Champliaud MF, Viel A, Baden HP (2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". J. Invest. Dermatol. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.CS1 maint: Multiple names: authors list (link)
• Kim KY, Shin SM, Kim JK; et al. (2004). "Heat shock factor regulates VDUP1 gene expression". Biochem. Biophys. Res. Commun. 315 (2): 369–75. doi:10.1016/j.bbrc.2004.01.047. PMID 14766217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schulze PC, Yoshioka J, Takahashi T; et al. (2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein". J. Biol. Chem. 279 (29): 30369–74. doi:10.1074/jbc.M400549200. PMID 15128745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coon H, Singh N, Dunn D; et al. (2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study". Atherosclerosis. 174 (2): 357–62. doi:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishinaka Y, Masutani H, Oka S; et al. (2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1". J. Biol. Chem. 279 (36): 37559–65. doi:10.1074/jbc.M405473200. PMID 15234975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aitken CJ, Hodge JM, Nishinaka Y; et al. (2005). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling". J. Bone Miner. Res. 19 (12): 2057–64. doi:10.1359/JBMR.040913. PMID 15537450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamawaki H, Pan S, Lee RT, Berk BC (2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells". J. Clin. Invest. 115 (3): 733–8. doi:10.1172/JCI200523001. PMID 15696199.CS1 maint: Multiple names: authors list (link)
• Minn AH, Hafele C, Shalev A (2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis". Endocrinology. 146 (5): 2397–405. doi:10.1210/en.2004-1378. PMID 15705778.CS1 maint: Multiple names: authors list (link)