UBE1L

Ubiquitin-activating enzyme E1-like
Identifiers
Symbols	UBE1L ; D8; MGC12713; UBE2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2502
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE UBE1L 1294 at tn.png
File:PBB GE UBE1L 203281 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin-activating enzyme E1-like, also known as UBE1L, is a human gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.

Further reading

• Carritt B, Kok K, van den Berg A; et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kok K, Van den Berg A, Veldhuis PM; et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMID 7734949.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kok K, Hofstra R, Pilz A; et al. (1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6071–5. PMID 8327486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McLaughlin PM, Helfrich W, Kok K; et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. PMID 10709110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMID 11157743.
• Kitareewan S, Pitha-Rowe I, Sekula D; et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. doi:10.1073/pnas.052011299. PMID 11891284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lenschow DJ, Giannakopoulos NV, Gunn LJ; et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMID 16254333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi T, Iwahara S, Saeki Y; et al. "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)