UBE2D2

Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
File:PBB Protein UBE2D2 image.jpg PDB rendering based on 1ur6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ur6​, 1w4u​, 1x23​, 1z2u​, 2c4o​, 2esk​, 2eso​, 2esp​, 2esq​, 2fuh​
Identifiers
Symbols	UBE2D2 ; UBC4/5; E2(17)KB2; PUBC1; UBC4; UBCH5B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86060
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UBE2D2 201343 at tn.png
File:PBB GE UBE2D2 201344 at tn.png
File:PBB GE UBE2D2 201345 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), also known as UBE2D2, is a human gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Further reading

• Rolfe M, Beer-Romero P, Glass S; et al. (1995). "Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3264–8. PMID 7724550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheffner M, Huibregtse JM, Howley PM (1994). "Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 8797–801. PMID 8090726.CS1 maint: Multiple names: authors list (link)
• Jensen JP, Bates PW, Yang M; et al. (1996). "Identification of a family of closely related human ubiquitin conjugating enzymes". J. Biol. Chem. 270 (51): 30408–14. PMID 8530467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hatakeyama S, Jensen JP, Weissman AM (1997). "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases". J. Biol. Chem. 272 (24): 15085–92. PMID 9182527.CS1 maint: Multiple names: authors list (link)
• Anan T, Nagata Y, Koga H; et al. (1999). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. PMID 9990509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonen H, Bercovich B, Orian A; et al. (1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". J. Biol. Chem. 274 (21): 14823–30. PMID 10329681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joazeiro CA, Wing SS, Huang H; et al. (1999). "The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase". Science. 286 (5438): 309–12. PMID 10514377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tongaonkar P, Chen L, Lambertson D; et al. (2000). "Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome". Mol. Cell. Biol. 20 (13): 4691–8. PMID 10848595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strack P, Caligiuri M, Pelletier M; et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang S, Ferrone M, Yang C; et al. (2002). "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14422–7. doi:10.1073/pnas.251401598. PMID 11724934.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu P, Chen Y, Tagle DA, Cai T (2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.CS1 maint: Multiple names: authors list (link)
• Xia Y, Pao GM, Chen HW; et al. (2003). "Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein". J. Biol. Chem. 278 (7): 5255–63. doi:10.1074/jbc.M204591200. PMID 12431996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeyama K, Aguiar RC, Gu L; et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu L, Yang L, Moitra PK; et al. (2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Exp. Cell Res. 288 (1): 84–93. PMID 12878161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Subramaniam V, Li H, Wong M; et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMID 14562029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimura H, Schwartz D, Gygi SP, Kosik KS (2004). "CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival". J. Biol. Chem. 279 (6): 4869–76. doi:10.1074/jbc.M305838200. PMID 14612456.CS1 maint: Multiple names: authors list (link)
• Lehner B, Semple JI, Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. PMID 14667819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winkler GS, Albert TK, Dominguez C; et al. (2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". J. Mol. Biol. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)