UCP3

Uncoupling protein 3 (mitochondrial, proton carrier)
Identifiers
Symbols	UCP3 ; SLC25A9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2517
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UCP3 219827 at tn.png
File:PBB GE UCP3 207349 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Uncoupling protein 3 (mitochondrial, proton carrier), also known as UCP3, is a human gene.

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene.

Further reading

• Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". Biochem. J. 345 Pt 2: 161–79. PMID 10620491.
• Muzzin P (2002). "The uncoupling proteins". Ann. Endocrinol. (Paris). 63 (2 Pt 1): 106–10. PMID 11994670.
• Boss O, Samec S, Paoloni-Giacobino A; et al. (1997). "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression". FEBS Lett. 408 (1): 39–42. PMID 9180264.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vidal-Puig A, Solanes G, Grujic D; et al. (1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem. Biophys. Res. Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gong DW, He Y, Karas M, Reitman M (1997). "Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin". J. Biol. Chem. 272 (39): 24129–32. PMID 9305858.CS1 maint: Multiple names: authors list (link)
• Solanes G, Vidal-Puig A, Grujic D; et al. (1997). "The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts". J. Biol. Chem. 272 (41): 25433–6. PMID 9325252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boss O, Giacobino JP, Muzzin P (1998). "Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13". Genomics. 47 (3): 425–6. doi:10.1006/geno.1997.5135. PMID 9480760.CS1 maint: Multiple names: authors list (link)
• Urhammer SA, Dalgaard LT, Sørensen TI; et al. (1998). "Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity". Diabetologia. 41 (2): 241–4. PMID 9498661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Argyropoulos G, Brown AM, Willi SM; et al. (1998). "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes". J. Clin. Invest. 102 (7): 1345–51. PMID 9769326.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acín A, Rodriguez M, Rique H; et al. (1999). "Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene". Biochem. Biophys. Res. Commun. 258 (2): 278–83. PMID 10329378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vidal-Puig AJ, Grujic D, Zhang CY; et al. (2000). "Energy metabolism in uncoupling protein 3 gene knockout mice". J. Biol. Chem. 275 (21): 16258–66. doi:10.1074/jbc.M910179199. PMID 10748196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. PMID 10772343.
• Pierrat B, Ito M, Hinz W; et al. (2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". Eur. J. Biochem. 267 (9): 2680–7. PMID 10785390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clapham JC, Arch JR, Chapman H; et al. (2000). "Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean". Nature. 406 (6794): 415–8. doi:10.1038/35019082. PMID 10935638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Esterbauer H, Oberkofler H, Krempler F; et al. (2000). "The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents". J. Biol. Chem. 275 (46): 36394–9. doi:10.1074/jbc.M005713200. PMID 10958796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lanouette CM, Chagnon YC, Rice T; et al. (2002). "Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study". J. Appl. Physiol. 92 (3): 1111–8. doi:10.1152/japplphysiol.00726.2001. PMID 11842047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins P, Bing C, McCulloch P, Williams G (2002). "Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans". Br. J. Cancer. 86 (3): 372–5. doi:10.1038/sj.bjc.6600074. PMID 11875702.CS1 maint: Multiple names: authors list (link)
• Hu X, Murphy F, Karwautz A; et al. (2002). "Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa". Mol. Psychiatry. 7 (3): 276–7. doi:10.1038/sj.mp.4001044. PMID 11920154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)