UGT2B15

UDP glucuronosyltransferase 2 family, polypeptide B15
Identifiers
Symbols	UGT2B15 ; UGT2B8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88643
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

UDP glucuronosyltransferase 2 family, polypeptide B15, also known as UGT2B15, is a human gene.

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]

Further reading

• Coffman BL, Tephly TR, Irshaid YM; et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase". Arch. Biochem. Biophys. 281 (1): 170–5. PMID 2116769.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases". Mol. Pharmacol. 31 (1): 27–34. PMID 3100939.
• Green MD, Clarke DJ, Oturu EM; et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols". Arch. Biochem. Biophys. 322 (2): 460–8. doi:10.1006/abbi.1995.1489. PMID 7574722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates". Drug Metab. Dispos. 22 (5): 799–805. PMID 7835232.CS1 maint: Multiple names: authors list (link)
• Monaghan G, Clarke DJ, Povey S; et al. (1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen F, Ritter JK, Wang MG; et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms". Biochemistry. 32 (40): 10648–57. PMID 8399210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guillemette C, Lévesque E, Beaulieu M; et al. (1997). "Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells". Endocrinology. 138 (7): 2998–3005. PMID 9202245.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lévesque E, Beaulieu M, Green MD; et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene". Pharmacogenetics. 7 (4): 317–25. PMID 9295060.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strassburg CP, Strassburg A, Nguyen N; et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 ( Pt 2): 489–98. PMID 10024527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tchernof A, Lévesque E, Beaulieu M; et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method". Clin. Endocrinol. (Oxf). 50 (5): 637–42. PMID 10468930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strassburg CP, Kneip S, Topp J; et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gsur A, Preyer M, Haidinger G; et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 11 (5): 497–8. PMID 12010866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iida A, Saito S, Sekine A; et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8". J. Hum. Genet. 47 (10): 505–10. doi:10.1007/s100380200075. PMID 12376738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Court MH, Duan SX, Guillemette C; et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9". Drug Metab. Dispos. 30 (11): 1257–65. PMID 12386133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression". Asian J. Androl. 5 (1): 9–13. PMID 12646996.CS1 maint: Multiple names: authors list (link)
• Zhang JY, Zhan J, Cook CS; et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism". Drug Metab. Dispos. 31 (5): 652–8. PMID 12695355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism". J. Pediatr. Endocrinol. Metab. 16 (5): 719–26. PMID 12880121.
• Court MH, Hao Q, Krishnaswamy S; et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver". J. Pharmacol. Exp. Ther. 310 (2): 656–65. doi:10.1124/jpet.104.067660. PMID 15044558.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toide K, Umeda S, Yamazaki H; et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15". Drug Metab. Pharmacokinet. 17 (2): 164–6. PMID 15618667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. PMID 15666817.CS1 maint: Multiple names: authors list (link)