USP18
| Ubiquitin specific peptidase 18 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | USP18 ; ISG43; UBP43 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8047 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE USP18 219211 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Ubiquitin specific peptidase 18, also known as USP18, is a human gene.[1]
USP18, a member of the deubiquitinating protease family of enzymes, removes ubiquitin adducts from a broad range of protein substrates.[supplied by OMIM][1]
References
Further reading
- Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
- Li XL, Blackford JA, Judge CS; et al. (2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response". J. Biol. Chem. 275 (12): 8880–8. PMID 10722734.
- Schwer H, Liu LQ, Zhou L; et al. (2000). "Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)". Genomics. 65 (1): 44–52. doi:10.1006/geno.2000.6148. PMID 10777664.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Kang D, Jiang H, Wu Q; et al. (2001). "Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH". Gene. 267 (2): 233–42. PMID 11313150.
- Malakhov MP, Malakhova OA, Kim KI; et al. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins". J. Biol. Chem. 277 (12): 9976–81. doi:10.1074/jbc.M109078200. PMID 11788588.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tokarz S, Berset C, La Rue J; et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase". J. Biol. Chem. 279 (45): 46424–30. doi:10.1074/jbc.M403189200. PMID 15342634.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
- Yan M, Luo JK, Ritchie KJ; et al. (2007). "Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling". Blood. 110 (1): 305–12. doi:10.1182/blood-2006-07-033209. PMID 17374743.
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