VCAN

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Versican
Identifiers
Symbols VCAN ; CSPG2; DKFZp686K06110; ERVR; PG-M; WGN; WGN1
External IDs Template:OMIM5 Template:MGI HomoloGene3228
RNA expression pattern
File:PBB GE VCAN 204620 s at tn.png
File:PBB GE VCAN 204619 s at tn.png
File:PBB GE VCAN 211571 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Versican, also known as VCAN, is a human gene.[1]


References

  1. "Entrez Gene: VCAN versican".

Further reading

  • Wight TN, Merrilees MJ (2004). "Proteoglycans in atherosclerosis and restenosis: key roles for versican". Circ. Res. 94 (9): 1158–67. doi:10.1161/01.RES.0000126921.29919.51. PMID 15142969.
  • Kenagy RD, Plaas AH, Wight TN (2006). "Versican degradation and vascular disease". Trends Cardiovasc. Med. 16 (6): 209–15. doi:10.1016/j.tcm.2006.03.011. PMID 16839865.
  • Perides G, Rahemtulla F, Lane WS; et al. (1992). "Isolation of a large aggregating proteoglycan from human brain". J. Biol. Chem. 267 (33): 23883–7. PMID 1429726.
  • Iozzo RV, Naso MF, Cannizzaro LA; et al. (1993). "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)". Genomics. 14 (4): 845–51. PMID 1478664.
  • Perides G, Lane WS, Andrews D; et al. (1989). "Isolation and partial characterization of a glial hyaluronate-binding protein". J. Biol. Chem. 264 (10): 5981–7. PMID 2466833.
  • Bignami A, Lane WS, Andrews D, Dahl D (1989). "Structural similarity of hyaluronate binding proteins in brain and cartilage". Brain Res. Bull. 22 (1): 67–70. PMID 2469524.
  • Zimmermann DR, Ruoslahti E (1990). "Multiple domains of the large fibroblast proteoglycan, versican". EMBO J. 8 (10): 2975–81. PMID 2583089.
  • Krusius T, Gehlsen KR, Ruoslahti E (1987). "A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences". J. Biol. Chem. 262 (27): 13120–5. PMID 2820964.
  • Naso MF, Zimmermann DR, Iozzo RV (1995). "Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter". J. Biol. Chem. 269 (52): 32999–3008. PMID 7528742.
  • Brown DM, Graemiger RA, Hergersberg M; et al. (1995). "Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14". Arch. Ophthalmol. 113 (5): 671–5. PMID 7748141.
  • Dours-Zimmermann MT, Zimmermann DR (1995). "A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican". J. Biol. Chem. 269 (52): 32992–8. PMID 7806529.
  • Zako M, Shinomura T, Ujita M; et al. (1995). "Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues". J. Biol. Chem. 270 (8): 3914–8. PMID 7876137.
  • Yao LY, Moody C, Schönherr E; et al. (1994). "Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry". Matrix Biol. 14 (3): 213–25. PMID 7921538.
  • Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF; et al. (1996). "Distribution of the large aggregating proteoglycan versican in adult human tissues". J. Histochem. Cytochem. 44 (4): 303–12. PMID 8601689.
  • Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR (1996). "Differential expression of versican isoforms in brain tumors". J. Neuropathol. Exp. Neurol. 55 (5): 528–33. PMID 8627343.
  • Sartipy P, Johansen B, Camejo G; et al. (1996). "Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity". J. Biol. Chem. 271 (42): 26307–14. PMID 8824283.
  • Aspberg A, Miura R, Bourdoulous S; et al. (1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10116–21. PMID 9294172.
  • Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes". Arterioscler. Thromb. Vasc. Biol. 18 (12): 1934–41. PMID 9848887.
  • Perveen R, Hart-Holden N, Dixon MJ; et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3". Genomics. 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161.
  • Lemire JM, Braun KR, Maurel P; et al. (1999). "Versican/PG-M isoforms in vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 19 (7): 1630–9. PMID 10397680.

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