WHSC2
| Wolf-Hirschhorn syndrome candidate 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | WHSC2 ; FLJ10442; FLJ25112; NELF-A; NELFA; P/OKcl.15 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 68478 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE WHSC2 34225 at tn.png | |||||||||
| File:PBB GE WHSC2 203112 s at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Wolf-Hirschhorn syndrome candidate 2, also known as WHSC2, is a human gene.[1]
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.[1] WHSC2 encodes the NELF-A subunit of the NELF complex.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: WHSC2 Wolf-Hirschhorn syndrome candidate 2".
- ↑ Narita, Takashi (2003). "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex". MOLECULAR AND CELLULAR BIOLOGY. 23: 1863–1873. doi:10.1128/MCB.23.6.1863-1873.2003. PMID 12612062. Unknown parameter
|coauthors=ignored (help)
Further reading
- Gutmajster E, Rokicka A (2003). "[Genetic determination of Wolf-Hirschhorn syndrome ]". Wiad. Lek. 55 (11–12): 706–10. PMID 12715353.
- Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMID 16838299.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Wright TJ, Ricke DO, Denison K; et al. (1997). "A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region". Hum. Mol. Genet. 6 (2): 317–24. PMID 9063753.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Yamaguchi Y, Takagi T, Wada T; et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation". Cell. 97 (1): 41–51. PMID 10199401.
- Wright TJ, Costa JL, Naranjo C; et al. (1999). "Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region". Genomics. 59 (2): 203–12. doi:10.1006/geno.1999.5871. PMID 10409432.
- Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation". J. Biol. Chem. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
- Mariotti M, Manganini M, Maier JA (2001). "Modulation of WHSC2 expression in human endothelial cells". FEBS Lett. 487 (2): 166–70. PMID 11150502.
- Ito M, Shichijo S, Tsuda N; et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
- Yamaguchi Y, Filipovska J, Yano K; et al. (2001). "Stimulation of RNA polymerase II elongation by hepatitis delta antigen". Science. 293 (5527): 124–7. doi:10.1126/science.1057925. PMID 11387440.
- Yamaguchi Y, Inukai N, Narita T; et al. (2002). "Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA". Mol. Cell. Biol. 22 (9): 2918–27. PMID 11940650.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Zollino M, Lecce R, Fischetto R; et al. (2003). "Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2". Am. J. Hum. Genet. 72 (3): 590–7. PMID 12563561.
- Narita T, Yamaguchi Y, Yano K; et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Mol. Cell. Biol. 23 (6): 1863–73. PMID 12612062.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
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