WNT7A

Wingless-type MMTV integration site family, member 7A
Identifiers
Symbols	WNT7A ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20969
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WNT7A 210248 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Wingless-type MMTV integration site family, member 7A, also known as WNT7A, is a human gene.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract, but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steriod hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor-alpha.

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. PMID 8167409.CS1 maint: Multiple names: authors list (link)
• Huguet EL, McMahon JA, McMahon AP; et al. (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. 54 (10): 2615–21. PMID 8168088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikegawa S, Kumano Y, Okui K; et al. (1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet. Cell Genet. 74 (1–2): 149–52. PMID 8893824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bui TD, Lako M, Lejeune S; et al. (1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. 189 (1): 25–9. PMID 9161407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parr BA, McMahon AP (1998). "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a". Nature. 395 (6703): 707–10. doi:10.1038/27221. PMID 9790192.
• Calvo R, West J, Franklin W; et al. (2001). "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12776–81. doi:10.1073/pnas.97.23.12776. PMID 11070089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li S, Chiang TC, Davis GR; et al. (2001). "Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma". J. Clin. Endocrinol. Metab. 86 (1): 454–7. PMID 11232041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Couse JF, Dixon D, Yates M; et al. (2002). "Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract". Dev. Biol. 238 (2): 224–38. doi:10.1006/dbio.2001.0413. PMID 11784006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caricasole A, Ferraro T, Iacovelli L; et al. (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins". J. Biol. Chem. 278 (39): 37024–31. doi:10.1074/jbc.M300191200. PMID 12857724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tuli R, Tuli S, Nandi S; et al. (2003). "Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk". J. Biol. Chem. 278 (42): 41227–36. doi:10.1074/jbc.M305312200. PMID 12893825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohira T, Gemmill RM, Ferguson K; et al. (2003). "WNT7a induces E-cadherin in lung cancer cells". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10429–34. doi:10.1073/pnas.1734137100. PMID 12937339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Timmreck LS, Pan HA, Reindollar RH, Gray MR (2004). "WNT7A mutations in patients with Müllerian duct abnormalities". Journal of pediatric and adolescent gynecology. 16 (4): 217–21. PMID 14550385.CS1 maint: Multiple names: authors list (link)
• Hwang SG, Ryu JH, Kim IC; et al. (2004). "Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms". J. Biol. Chem. 279 (25): 26597–604. doi:10.1074/jbc.M401401200. PMID 15082716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winn RA, Marek L, Han SY; et al. (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". J. Biol. Chem. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lyu J, Joo CK (2005). "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing". J. Biol. Chem. 280 (22): 21653–60. doi:10.1074/jbc.M500374200. PMID 15802269.
• Woods CG, Stricker S, Seemann P; et al. (2006). "Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome". Am. J. Hum. Genet. 79 (2): 402–8. doi:10.1086/506332. PMID 16826533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winn RA, Van Scoyk M, Hammond M; et al. (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindberg D, Akerström G, Westin G (2007). "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours". Clin. Endocrinol. (Oxf). 66 (1): 110–4. doi:10.1111/j.1365-2265.2006.02694.x. PMID 17201809.CS1 maint: Multiple names: authors list (link)