WWOX

WW domain containing oxidoreductase
File:PBB Protein WWOX image.jpg PDB rendering based on 1wmv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wmv​
Identifiers
Symbols	WWOX ; FRA16D; D16S432E; FOR; HHCMA56; PRO0128; WOX1; WWOX v8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56334
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WWOX 221147 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WW domain containing oxidoreductase, also known as WWOX, is a human gene.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Further reading

• Ramos D, Aldaz CM (2007). "WWOX, a chromosomal fragile site gene and its role in cancer". Adv. Exp. Med. Biol. 587: 149–59. PMID 17163164.
• Bednarek AK, Laflin KJ, Daniel RL; et al. (2000). "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Cancer Res. 60 (8): 2140–5. PMID 10786676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ried K, Finnis M, Hobson L; et al. (2000). "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells". Hum. Mol. Genet. 9 (11): 1651–63. PMID 10861292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang NS, Pratt N, Heath J; et al. (2001). "Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity". J. Biol. Chem. 276 (5): 3361–70. doi:10.1074/jbc.M007140200. PMID 11058590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paige AJ, Taylor KJ, Taylor C; et al. (2001). "WWOX: a candidate tumor suppressor gene involved in multiple tumor types". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11417–22. doi:10.1073/pnas.191175898. PMID 11572989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bednarek AK, Keck-Waggoner CL, Daniel RL; et al. (2001). "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth". Cancer Res. 61 (22): 8068–73. PMID 11719429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuroki T, Trapasso F, Shiraishi T; et al. (2002). "Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma". Cancer Res. 62 (8): 2258–60. PMID 11956080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang NS, Doherty J, Ensign A (2003). "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis". J. Biol. Chem. 278 (11): 9195–202. doi:10.1074/jbc.M208373200. PMID 12514174.CS1 maint: Multiple names: authors list (link)
• Ludes-Meyers JH, Bednarek AK, Popescu NC; et al. (2004). "WWOX, the common chromosomal fragile site, FRA16D, cancer gene". Cytogenet. Genome Res. 100 (1–4): 101–10. doi:10.1159/000072844. PMID 14526170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe A, Hippo Y, Taniguchi H; et al. (2004). "An opposing view on WWOX protein function as a tumor suppressor". Cancer Res. 63 (24): 8629–33. PMID 14695174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen ST, Chuang JI, Wang JP; et al. (2004). "Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system". Neuroscience. 124 (4): 831–9. doi:10.1016/j.neuroscience.2003.12.036. PMID 15026124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishii H, Mimori K, Vecchione A; et al. (2004). "Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX". Biochem. Biophys. Res. Commun. 316 (4): 1088–93. doi:10.1016/j.bbrc.2004.02.159. PMID 15044096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludes-Meyers JH, Kil H, Bednarek AK; et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMID 15064722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aqeilan RI, Pekarsky Y, Herrero JJ; et al. (2004). "Functional association between Wwox tumor suppressor protein and p73, a p53 homolog". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4401–6. doi:10.1073/pnas.0400805101. PMID 15070730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuroki T, Yendamuri S, Trapasso F; et al. (2004). "The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis". Clin. Cancer Res. 10 (7): 2459–65. PMID 15073125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guler G, Uner A, Guler N; et al. (2004). "The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma". Cancer. 100 (8): 1605–14. doi:10.1002/cncr.20137. PMID 15073846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sze CI, Su M, Pugazhenthi S; et al. (2004). "Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease". J. Biol. Chem. 279 (29): 30498–506. doi:10.1074/jbc.M401399200. PMID 15126504.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aqeilan RI, Kuroki T, Pekarsky Y; et al. (2004). "Loss of WWOX expression in gastric carcinoma". Clin. Cancer Res. 10 (9): 3053–8. PMID 15131042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park SW, Ludes-Meyers J, Zimonjic DB; et al. (2004). "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma". Br. J. Cancer. 91 (4): 753–9. doi:10.1038/sj.bjc.6602023. PMID 15266310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)