WWP1

WW domain containing E3 ubiquitin protein ligase 1
File:PBB Protein WWP1 image.jpg PDB rendering based on 1nd7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1nd7​
Identifiers
Symbols	WWP1 ; AIP5; DKFZp434D2111; Tiul1; hSDRP1
External IDs	Template:OMIM5 HomoloGene: 21385
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WWP1 212637 s at tn.png
File:PBB GE WWP1 212638 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WW domain containing E3 ubiquitin protein ligase 1, also known as WWP1, is a human gene.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Pirozzi G, McConnell SJ, Uveges AJ; et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wood JD, Yuan J, Margolis RL; et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mosser EA, Kasanov JD, Forsberg EC; et al. (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains". Biochemistry. 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.CS1 maint: Multiple names: authors list (link)
• Flasza M, Gorman P, Roylance R; et al. (2002). "Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein". Biochem. Biophys. Res. Commun. 290 (1): 431–7. doi:10.1006/bbrc.2001.6206. PMID 11779188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galinier R, Gout E, Lortat-Jacob H; et al. (2003). "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases". Biochemistry. 41 (48): 14299–305. PMID 12450395.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verdecia MA, Joazeiro CA, Wells NJ; et al. (2003). "Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase". Mol. Cell. 11 (1): 249–59. PMID 12535537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Komuro A, Imamura T, Saitoh M; et al. (2004). "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)". Oncogene. 23 (41): 6914–23. doi:10.1038/sj.onc.1207885. PMID 15221015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seo SR, Lallemand F, Ferrand N; et al. (2005). "The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation". EMBO J. 23 (19): 3780–92. doi:10.1038/sj.emboj.7600398. PMID 15359284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen C, Sun X, Guo P; et al. (2006). "Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells". J. Biol. Chem. 280 (50): 41553–61. doi:10.1074/jbc.M506183200. PMID 16223724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flasza M, Nguyen Huu NS, Mazaleyrat S; et al. (2006). "Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch". Mol. Membr. Biol. 23 (3): 269–76. doi:10.1080/09687860600665010. PMID 16785210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laine A, Ronai Z (2007). "Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1". Oncogene. 26 (10): 1477–83. doi:10.1038/sj.onc.1209924. PMID 16924229.
• Chen C, Sun X, Guo P; et al. (2007). "Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer". Oncogene. 26 (16): 2386–94. doi:10.1038/sj.onc.1210021. PMID 17016436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)