ZFY

Zinc finger protein, Y-linked
File:PBB Protein ZFY image.jpg PDB rendering based on 1klr.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1klr​, 5znf​
Identifiers
Symbols	ZFY ; MGC138710
External IDs	Template:OMIM5 HomoloGene: 88465
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE ZFY 207247 s at tn.png
File:PBB GE ZFY 207246 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Zinc finger protein, Y-linked, also known as ZFY, is a human gene.

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.

Further reading

• Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells". Arch. Med. Res. 32 (6): 553–8. PMID 11750730.
• Kochoyan M, Havel TF, Nguyen DT; et al. (1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition". Biochemistry. 30 (14): 3371–86. PMID 1849423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kochoyan M, Keutmann HT, Weiss MA (1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition". Biochemistry. 30 (29): 7063–72. PMID 1854720.CS1 maint: Multiple names: authors list (link)
• North M, Sargent C, O'Brien J; et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Res. 19 (10): 2579–86. PMID 2041734.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palmer MS, Berta P, Sinclair AH; et al. (1990). "Comparison of human ZFY and ZFX transcripts". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. PMID 2308929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Müller G, Schempp W (1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum. Genet. 82 (1): 82–4. PMID 2497060.
• Affara NA, Chambers D, O'Brien J; et al. (1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9". Nucleic Acids Res. 17 (8): 2987–99. PMID 2498838.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lau YF, Chan KM (1990). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues". Am. J. Hum. Genet. 45 (6): 942–52. PMID 2511751.
• Page DC, Mosher R, Simpson EM; et al. (1988). "The sex-determining region of the human Y chromosome encodes a finger protein". Cell. 51 (6): 1091–104. PMID 3690661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tricoli JV, Bracken RB (1993). "ZFY gene expression and retention in human prostate adenocarcinoma". Genes Chromosomes Cancer. 6 (2): 65–72. PMID 7680890.
• Erlandsson R, Wilson JF, Pääbo S (2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans". Mol. Biol. Evol. 17 (5): 804–12. PMID 10779541.CS1 maint: Multiple names: authors list (link)
• Mittwoch U (2001). "Three thousand years of questioning sex determination". Cytogenet. Cell Genet. 91 (1–4): 186–91. PMID 11173854.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ; et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)