Inappropriate sinus tachycardia medical therapy

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Inappropriate sinus tachycardia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Medical Therapy

Pharmacotherapy

Treatments in the form of pharmacological therapy or catheter ablation are available, although it is currently difficult to treat successfully.

Beta-blockers

In so far as the pathophysiology of IST involves abnormal sensitivity to adrenaline, betaa-blockers can be helpful.

Calcium Channel Blockers

Although calcium channel blockers slow conduction through the AV node, they have been marginally effective in the treatment of IST.

Ivabradine

A new selective sinus node inhibitor Ivabradine is also being used to treat IST.

Treatments Related to Dysautonomia and POTS

In so far as the underlying pathophysiology may involve a dysautonomia and features of Postural orthostatic tachycardia syndrome (POTS), some therapies more commonly used to treat these disorders have been tried:

Fludrocortisone (Florinef)

POTS and dysautonomia have been associated with decreases in blood volume, and this drug promotes sodium retention.

Midodrine

Midodrine increases vasoconstriction, and prevents falls in blood pressure.

Serotonin-reuptake inhibitors (SSRIs)

SSRIs have proven effective in treating some patients with dysautonomia.

References