Splenic marginal zone lymphoma physical examination
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4]
Overview
Physical Examination
With splenic involvement a sine qua non for SMZL, splenomegaly is seen in almost all patients, commonly without lymphadenopathy.[1] Reactive germinal centers in splenic white pulp are replaced by small neoplastic lymphocytes that efface the mantle zone and ultimately blend in with the marginal zone with occasional larger neoplastic cells that resemble blasts.[2][3] The red pulp is always involved, with both nodules of larger neoplastic cells and sheets of the small neoplastic lymphocytes. Other features that may been seen include sinus invasion, epithelial histocytes, and plasmacytic differentiation of neoplastic cells.
References
- ↑ [1] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues. IARC Press: Lyon 2001
- ↑ [2] Mollejo M, Menarguez J, Lloret E, Sanchez A, Campo E, Algara P, Cristobal E, Sanchez E, Piris MA. "Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases." Am J Surg Pathol. 1995 Oct;19(10):1146-57. PMID: 7573673
- ↑ [3] Jaffe ES, Costa J, Fauci AS, Cossman J, Tsokos M. "Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis." Am J Med. 1983 Nov;75(5):741-9. PMID: 6638043