Euthyroid sick syndrome

Euthyroid sick syndrome
ICD-10	E07.8
ICD-9	790.94
MeSH	D005067

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753

Synonyms and keywords: Euthyroid sick syndrome; sick euthyroid syndrome; non-thyroidal illness syndrome; low T3 low T4 syndrome

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Overview

Euthyroid sick syndrome is a thyroid hormone disorder where the levels of T3 and/or T4 are at unusual levels, but the thyroid gland does not appear to be dysfunctional.

Differential Diagnosis of Causes

Fasting, starvation, sepsis, trauma, cardiopulmonary bypass, malignancy, heart failure, hypothermia, myocardial infarction, chronic renal failure, cirrhosis, and diabetic ketoacidosis.

Diagnosis

Ill patients may have normal to low TSH depending on the spectrum of illness. Total T4 and T3 levels may be altered by binding protein abnormalities, and medications. Reverse T3 are generally increased signifying inhibition of normal Type 1 enzyme or reduced clearance of reverse T3. Measurement of free T4 and/or free T3 levels will be normal.

External links

• McIver B, Gorman C (1997). "Euthyroid sick syndrome: an overview". Thyroid. 7 (1): 125–32. PMID 9086580.