Laron syndrome
For patient information click here
| Laron syndrome | |
 | |
|---|---|
| Growth hormone | |
| ICD-10 | E34.3 |
| ICD-9 | 259.4 |
| OMIM | 262500 245590 |
| DiseasesDB | 7262 |
| MeSH | D046150 |
|
Laron syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Laron syndrome On the Web |
|
American Roentgen Ray Society Images of Laron syndrome |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S
Synonyms and keywords: Growth Harmone Receptor Deficiency; Growth hormone insensitivity syndrome; pituitary dwarfism II; Laron syndrome due to postreceptor defect; growth hormone insensitivity due to postreceptor defect; Laron-type dwarfism
Diagnosis
Symptoms
The principal feature of Laron syndrome is abnormally short stature (dwarfism). Symptoms include:
- Truncal obesity[1]
- Seizures are frequently secondary to hypoglycemia.
- Some genetic variations have an impact upon intellectual capacity.[2]
Physical Examination
Physical exam findings include:
Treatment
Treatment may include administration of IGF-1.
References
- ↑ Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N (2006). "Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity)". Clin. Endocrinol. (Oxf). 65 (1): 114–7. doi:10.1111/j.1365-2265.2006.02558.x. PMID 16817829.
- ↑ Shevah O, Kornreich L, Galatzer A, Laron Z (2005). "The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities". Horm. Metab. Res. 37 (12): 757–60. doi:10.1055/s-2005-921097. PMID 16372230.