Glucocorticoid resistance

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Synonyms and keywords: Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess

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Overview

Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be

1. Generalized or tissue-specific
2. Transient or permanent
3. Partial or complete
4. Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WS