Hypoadrenia pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Biologically, long term stress is a modern phenomenon in the human environment (in evolutionary terms through most of human and mammalian history, stress was a reaction to a point incident, rather than a continuing way of life). As a result, the human body and its internal regulatory mechanisms are poorly adapted to handling many aspects of the types of stress found in civilized cultures. They evolved, so to speak, to react to predator attacks, rather than (for example) constant belittlement, decades long abuse, high risk hobbies, pressure to succeed, or existential and religious inspired worries about ones life and future.
Organs such as the brain, the endocrine system-- including the sympathetic and parasympathetic systems, and the various glands contained therein, which were not evolved for, or designed to handle and respond optimally to, constant stimulation may therefore, under modern social conditions, become constantly or abnormally stimulated. Other organs which form part of the whole, such as the nervous and musculoskeletal system, are also made to work for decades under different (and comparatively abnormal) conditions than existed throughout the rest of human evolution.
It has been hypothesised by alternative medical practitioners, but not clinically proven, that under certain long term stress and physical conditions, that the body's stress management systems cease to regulate stress and stress related body systems and hormones appropriately, and instead become adapted to continual over stimulation in various inappropriate ways which can lead to the symptoms described. This is strictly hypothetical, and by no means universally accepted, particularly in mainstream medicine.