Castleman's disease pathophysiology

Castleman's disease Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

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Pathophysiology

In all cases, Castleman's disease is likely due to hypersecretion of the cytokine IL-6. In KSHV positive tumors, this is most likely due to expression of the a virus-encoded cytokine, vIL-6, while KSHV negative tumors appear to be the result of over secretion of human IL-6.

Associated Conditions

Castleman's disease is sometimes associated with:

• POEMS syndrome
• Paraneoplastic pemphigus
• Thrombotic thrombocytopenic purpura (TTP)