Idiopathic thrombocytopenic purpura causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

The cause of ITP is thought to be related to chronic infections such as HIV, hepatitis C and H. Pylori.

• ITP occurs when certain immune system cells produce antibodies against platelets. Platelets help blood clot by clumping together to plug small holes in damaged blood vessels.

• The antibodies attach to the platelets. The spleen destroys the platelets that carry the antibodies.

• In children, the disease sometimes follows a viral infection. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder.

• ITP affects women more frequently than men, and is more common in children than adults. The disease affects boys and girls equally.