Hereditary persistence of fetal hemoglobin

Hereditary persistence of fetal hemoglobin
ICD-10	D56.4
ICD-9	282.7

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Hereditary persistence of foetal hemoglobin; HPFH

Overview

Hereditary persistence of fetal hemoglobin is a benign condition in which significant fetal hemoglobin (hemoglobin F) production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.

Causes

This is usually caused by mutations in the β-globin gene cluster. The percentage of incorrect expression might be as low as 10-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes.

Epidemiology and Demographics

HPFH may alleviate the severity of certain hemaglobinopathies and thalassemias, and is selected for in populations with a high prevalence of these conditions (which in turn are often selected for in areas where malaria is endemic). Thus, it has been found to affect black people, as well as Greeks.

Diagnosis

Symptoms

The condition is usually asymptomatic, and is only noticed when screening for other hemoglobin disorders.

References

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