Anaphylaxis overview

Anaphylaxis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anaphylaxis is an acute systemic (multi-system) and severe Type I Hypersensitivity allergic reaction in humans and other mammals. The term comes from the Greek words ana (against) and phylaxis (protection). Anaphylaxis occurs when a person or animal is exposed to a trigger substance, called an allergen, to which they have already become sensitized. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. Anaphylaxis may occur after ingestion, skin contact, injection of an allergen or, in rare cases, inhalation.