Pulmonary nodule medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Medical Therapy

Recommendations for Follow-up and Management of Nodules <8 mm Detected Incidentally at Non-screening CT

Nodule Size (mm) Low risk patients High risk patients
Less than or equal to 4 No follow-up needed. Follow-up at 12 months. If no change, no further imaging needed.
>4 - 6 Follow-up at 12 months. If no change, no further imaging needed. Initial follow-up CT at 6 -12 months and then at 18 - 24 months if no change.
>6 - 8 Initial follow-up CT at 6 -12 months and then at 18 - 24 months if no change. Initial follow-up CT at 3 - 6 months and then at 9 -12 and 24 months if no change.
>8 Follow-up CTs at around 3, 9, and 24 months. Dynamic contrast enhanced CT, PET, and/or biopsy Same at for low risk patients

Note: Newly detected indeterminate nodule in persons 35 years of age or older.[1]

  • Low risk patients: Minimal or absent history of smoking and of other known risk factors.
  • High risk patients: History of smoking or of other known risk factors.


References

  1. Heber MacMahon, John H. M. Austin, Gordon Gamsu, Christian J. Herold, James R. Jett, David P. Naidich, Edward F. Patz, Jr, and Stephen J. Swensen. Guidelines for Management of Small Pulmonary Nodules Detected on CT Scans: A Statement from the Fleischner Society. Radiology 2005 237: 395-400.

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