Eplerenone Post-Ami Heart Failure Efficacy And Survival Study
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Acronym
EPHESUS stands for Eplerenone Post-AMI Heart Failure Efficacy and Survival Trial.
Background
Eplerenone is an aldosterone antagonist that blocks the mineralocorticoid receptor. In contrast to spironolactone, it does not block the glucocorticoid, progesterone, or androgen receptors and for that reason it may may be associated with fewer side effects than spironolactone. Pre clinical studies have demonstrated that aldosterone antagonism may improve ventricular remodeling and collagen formation among patients who sustain LV dysfunction following an MI.
The EPHESUS study builds upon the RALES study (Randomized Aldactone Evaluation Study) which demonstrated that aldosterone inhibition with the older agent spironolactone reduced mortality when added to an ACE inhibitor among patients with severe congestive heart failure. In the older RALES study, only 10% of patients were on a beta blocker, and the benefit of an aldosterone antagonist on top of beta blockade was not adequately tested.
Results
|
End point
|
Eplerenone, No. (%)
|
Placebo, No. (%)
|
Relative risk (95% CI)
|
p
|
| Mortality* | 478 (14.4) | 554 (16.7) | 0.85 (0.75-0.96) |
0.008 |
| Cardiovascular mortality | 407 (12.3) | 483 (14.6) | 0.83 (0.72-0.94) |
0.005 |
| CV mortality or hospitalization for CV events* | 885 (26.7) | 993 (30.0) | 0.87 (0.79-0.95) |
0.002 |
*Primary end points
Number Needed to Treat (NNT) = 50 patients to save one life, and 33 to prevent one cardiovascular death or rehospitalization.
Summary
Among MI patients with LV dysfunction, the administration of eplerenone (Inspra®, Pharmacia) in addition to evidence based therapy is associated with a 15% reduction in all cause mortality. In addition, cardiovascular death, and CV death and hospitalization were also significantly reduced.