Brugada syndrome drugs to avoid

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The following drugs should be avoided in patients with Brugada syndrome.

Generic name	Brand name®	Class / Clinical use	References	Recommendation
Ajmaline	e.g. Gilurytmal® - more brand names here -	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Brugada 1997 Rolf 2003 Wolpert 2005 Bébarová 2005	Class I
Flecainide	e.g. Tambocor® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Krishnan 1998 Brugada 2000 Gasparini 2003 Meregalli 2006 Stokoe 2007	Class I
Pilsicainide	e.g. Sunrhythm® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Takenaka 1999 Fujiki 1999 Takagi 2002 Kimura 2004	Class I
Procainamide	e.g. Procan® Pronestyl® - more brand names here -	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Miyazaki 1996 Brugada 1997 Joshi 2007 Villemaire 1992	Class I
Propafenone	e.g. Rythmol® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Matana 2000 Akdemir 2002 Hasdemir 2006 Shan 2008 Stark 1996	Class IIa

Recommendation: Class I: convincing evidence/opinion; Class IIa: evidence/opinion less clear; Class IIb: conflicting evidence/opinion; Class III: very little evidence.