Atrial septal defect ostium secundum pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Most of ostium secundum ASDs occur sporadically. However, ostium secundum ASD has been found to occur with increased frequency in association with some genetic disorders including:
- Holt-Oram (heart-hand) syndrome
- Down syndrome
- Noonan syndrome
- Treacher Collins syndrome
- Thrombocytopenia-absent radii (TAR) syndrome
- Mitral valve prolapse: 10% to 20 % of individuals with ostium secundum ASDs also have mitral valve prolapse.[1]
References
- ↑ Leachman R, Cokkinos D, Cooley D (1976). "Association of ostium secundum atrial septal defects with mitral valve prolapse". Am J Cardiol. 38 (2): 167–9. PMID 952260.