Alcoholic liver disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural history, Complications and Prognosis
Complications
Alcoholic hepatitis
- Portal hypertension (ascites, variceal bleeding, hepatorenal syndrome)
- Coagulopathy
- Intractable jaundice
Cirrhosis
- Hepatocellular carcinoma
- Hepatic encephalopathy
Prognosis
In absence of steroid therapy 1 in every three patient dies.
Poor Prognostic factors
- Prolonged prothrombin time
- Serum Bilirubin >10 mg/dL
- Hepatic encephalopathy
- Azotemia
- Leukocytosis
- Unresponsive to steroid treatment
- Reversal portal flow on doppler USG
Prognostic scores
- MELD score for cirrhosis
- Glasgow alcoholic hepatitis score (age, white blood cell, blood urea nitrogen, prothrombin time ratio, and bilirubin level)
- ABIC score - age, serum bilirubin, serum creatinine
2010 AASLD/ACG Alcoholic Liver Disease Guidelines : Prognostic Factors (DO NOT EDIT)[1]
Class I |
1. " (Level of evidence: B) "
References
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