Keratoconjunctivitis sicca pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Having dry eyes for a while can lead to tiny abrasions on the surface of the eyes.[1] In advanced cases, the epithelium undergoes pathologic changes, namely squamous metaplasia and loss of goblet cells. Some severe cases result in thickening of the corneal surface,[2] corneal erosion, punctate keratopathy, epithelial defects, corneal ulceration (sterile and infected), corneal neovascularization, corneal scarring,[2] corneal thinning, and even corneal perforation.