Methicillin resistant staphylococcus aureus natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Natural History
- People in good health with a healthy immune system recover well from MRSA infections.
- Immunodeficiency patients suffer from severe forms of the disease, resulting in complications.
Complications
Complications of MRSA infection depends on the site of involvement. Some of the complications include:
- Septicemia
- Endocarditis
- Osteomyelitis
- Septic arthritis
- Pneumonia
- Necrotizing fasciitis
- Toxic shock syndrome
- CA-MRSA is associated with thrombosis
- Death
Prognosis
The major issue is that there are a number of factors that can lead to someone's death, and it is believed that patients with MRSA bacteraemia are sicker and will consequently have a higher mortality rate because of their underlying illness. However, several studies, including one by Blot and colleagues, have adjusted for underlying disease, and they still found MRSA bacteraemia to have a higher attributable mortality than MSSA bacteraemia.