Japanese encephalitis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Mild infections occur without apparent symptoms other than fever with headache. More severe infection is marked by quick onset, headache, high fever, neck stiffness, stupor, disorientation, coma, tremors, occasional convulsions (especially in infants) and spastic (but rarely flaccid) paralysis.

Symptoms

The incubation period for Japanese encephalitis is usually from 5 to 15 days.

• Less than 1% of people infected with Japanese encephalitis (JE) virus develop clinical illness.
• In persons who develop symptoms, the incubation period (time from infection until illness) is typically 5-15 days.
• Initial symptoms often include fever, headache, and vomiting.
• Mental status changes, neurologic symptoms, weakness, and movement disorders might develop over the next few days.
• Seizures are common, especially among children.
• More severe infection is marked by quick onset, headache, high fever, neck stiffness, stupor, disorientation, coma, tremors, occasional convulsions (especially in infants) and spastic (but rarely flaccid) paralysis.