Syphilis

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Medical Therapy Primary and Secondary Syphilis Latent Syphilis Tertiary Syphilis Neurosyphilis HIV-Infected Patients Pregnancy Management of Sexual Partners
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Classification

Congenital syphilis | Acquired syphilis | Neurosyphilis | Syphilitic aortitis | Tabes dorsalis

Pathophysiology

Primary syphilis | Secondary syphilis | Latent syphilis | Tertiary syphilis

Epidemiology & Demographics

United States | Age | Impact of Gender | Race & Ethnicity

Diagnosis

• History & symptoms: Primary syphilis | Secondary syphilis | Latent syphilis | Tertiary syphilis

• Physical examination: Chancre | Condylomata lata | Gumma

• Diagnostic tests:

• Serology: Non-treponemal test | Treponemal test | Immunoassay

• Dark field microscopy

• CSF analysis

Treatment

• Pharmacotherapy: Pencillin G therapy | Pencillin allergy | Jarisch-Herxheimer reaction

• Management based on stages: Primary & Secondary syphilis | Latent syphilis | Tertiary syphilis | Neurosyphilis

• Specific population: HIV-infected patients | Pregnancy | Management of sexual partners

• Prevention: Primary Prevention | Secondary Prevention

Related Chapters

• Tuberculosis (TB)
• Dyphtheria
• Side-chain theory
• Treponema pallidum
• Globalization and disease
• Pandemic

Resources

• UCSF HIV InSite Knowledge Base Chapter: Syphilis and HIV
• "A New Gold Standard For Syphilis?" Poster Presentation for European Academy of Dermatology and Venereology 2004 Spring Symposium
• Syphilis Pictures and Information
• Kipkeepers, Pox and Gleet Vendors: A Rapid History of Syphilis
• POX: Genius, Madness, and the Mysteries of Syphilis
• Syphilis Informational resource
• Secrets of the Dead (PBS): The Syphilis Enigma
• Syphilis and AIDS: Lessons from history
• "Syphilis fact sheet" from the Center for Disease Control
• The treatment of dementia paralytica by malaria inoculation (A Nobel Prize lecture, December 13, 1927)
• National Institute of Allergy and Infectious Diseases Factsheet
• New study blames Columbus for syphilis spread from Reuters Jan 15, 2008

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