Hepatitis B diagnostic criteria
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Hepatitis B |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Diagnostic Criteria
| Stage of Hepatitis B | Lab Findings |
|---|---|
| Chronic State | 1. HBsAg-positive >6 months |
| 2. Serum HBV DNA >20,000 IU/mL (105copies/mL), lower values 2,000-
20,000 IU/mL (104-105copies/mL) are often seen in HBeAg-negative chronic hepatitis B | |
| 3. Persistent or intermittent elevation in ALT/AST levels | |
| 4. Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation | |
| Carrier State | 1. HBsAg-positive >6 months |
| 2. HBeAg–, anti-HBe+ | |
| 3. Serum HBV DNA <2,000 IU/mL | |
| 4. Persistently normal ALT/AST levels | |
| 5. Liver biopsy confirms absence of significant hepatitis | |
| Resolved | 1. Previous known history of acute or chronic hepatitis B or the presence of anti-HBc ± anti-HBs |
| 2. HBsAg- | |
| 3. Undetectable serum HBV DNA | |
| 4. Normal ALT levels |