Anaphylaxis overview

Anaphylaxis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anaphylaxis is an acute systemic (multi-system) and severe Type I Hypersensitivity allergic reaction in humans and other mammals. Anaphylaxis occurs when a person or animal is exposed to a trigger substance, called an allergen, to which they have already become sensitized. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. Anaphylaxis may occur after ingestion, skin contact, injection of an allergen or, in rare cases, inhalation.

Historical Perspective

The term comes from the Greek words ana (against) and phylaxis (protection).