Toxic epidermal necrolysis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN.[1] The drugs most often implicated in TEN are antibiotics such as sulfonamides; nonsteroidal anti-inflammatory drugs; allopurinol,antiretroviral drugs; and corticosteroids; and anticonvulsants such as phenobarbital, phenytoin, carbamazepine, and valproic acid.[1] The condition might also result from immunizations, infection with agents such as Mycoplasma pneumoniae or the herpes virus; and transplants of bone marrow or organs.[1]