Alcoholic liver disease other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Liver biopsy is used to confirm the diagnosis when alcoholic hepatitis is suspected, and to help in guiding medical treatment. Microscopic findings on biopsy that indicate alcoholic hepatitis are: polymorphonuclear infiltration of cells, hepatic necrosis, ballooning hepatocytes, Mallory bodies within cells, and perivenular and perisinusoidal fibrosis.

Other Diagnostic Studies

Liver Biopsy

• Fatty liver
  • Macrovesicular fat
• Alcoholic hepatitis
  • Polymorphonuclear infiltration
  • Hepatic necrosis
  • Mallory bodies in hepatocytes
  • Perivenular and perisinusoidal fibrosis
  • Ballooning hepatocytes
  • Steatosis
• Alcoholic cirrhosis
  • Micronodular cirrhosis

2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)

Biopsy : Guidelines (DO NOT EDIT)

Class I

1. " For patients with a clinical diagnosis of severe alcoholic hepatitis (AH) for whom medical treatment is contemplated, or for those in whom reasonable uncertainty exists regarding the underlying diagnosis, a liver biopsy should be considered. This decision will depend on local expertise and ability in performing a liver biopsy in patients with coagulopathy, the patient’s severity of illness, and the type of therapy under consideration (Level of evidence: C) "