High density lipoprotein natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Overview
The plasma levels of HDL are inversely proportional to the development of coronary artery disease (CAD) making HDL a positive cardiac risk factor.[1] Low serum HDL-cholesterol can be an isolated abnormality or can be associated with hypercholesterolemia. Patients with premature coronary artery disease, defined as CAD in men less than 55 to 60 years of age and women less than 65 years of age, have a primary reduction in HDL-cholesterol. Studies have shown that low HDL risk is independent of the risk attributed to elevated LDL-cholesterol (low density lipoprotein) in the serum.
Low HDL and Cardiovascular Risk
The Framingham Heart Study has shown that the risk of myocardial infarction increases by about 25% for every 5 mg/dL decrement in serum HDL-cholesterol below median values for both men and women.[2]
References
- ↑ Rajagopal G, Suresh V, Sachan A (2012). "High-density lipoprotein cholesterol: How High". Indian J Endocrinol Metab. 16 (Suppl 2): S236–8. doi:10.4103/2230-8210.104048. PMC 3603035. PMID 23565387. Unknown parameter
|month=ignored (help) - ↑ Wilson PW, Abbott RD, Castelli WP (1988). "High density lipoprotein cholesterol and mortality. The Framingham Heart Study". Arteriosclerosis. 8 (6): 737–41. PMID 3196218.