Chronic hypertension laboratory findings
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Hypertension Main page |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor-In-Chief: Taylor Palmieri, Yazan Daaboul, Serge Korjian
Overview
Patients identified to be hypertensive must have an initial work-up to identify the presence and extent of target organ damage. Initial work-up is important because it recognizes initial baseline values that can aid the patient and the healthcare provider in assessing the evolution of hypertension and its complications with follow-up visits and lab tests. A more extensive work-up is only indicated when hypertension is not controlled with appropriate therapy or initial laboratory testing suggests a specific etiology of secondary hypertension. Diabetes and raised cholesterol levels being additional risk factors for the development of cardiovascular disease are also tested for as they will also require management.
Laboratory Tests
Blood tests commonly performed include:
- Creatinine is measured in order to assess GFR, identify both underlying renal disease as a cause of hypertension and conversely hypertension causing kidney damage and monitor the possible side-effects of certain antihypertensive drugs
- Electrolytes (sodium, potassium)
- Glucose level is measured in order to screen for diabetes mellitus
- Lipid panel including total cholesterol, LDL, HDL and triglycerides
- Glucose
- Blood urea nitrogen (BUN) / creatinine
- Calcium
- Urinalysis
- Urinary albumin excretion
- Albumin/Creatine ratio
Diagnostic Tests for Secondary Hypertension
Below is a table summarizing the diagnostic tests used in the case of secondary hypertension:[1]
| Diagnosis | Diagnostic Tests |
| Chronic kidney disease | Estimate GFR |
| Coarctation of aorta | CT angiography |
| Cushing's syndrome and other glucocorticoid excess states including chronic steroid therapy | History; dexamethasone suppression test |
| Drug induced/related | History; drug screening |
| Pheochromocytoma | 24 hour urinary metanephrine and normetanephrine |
| Primary aldosteronism and other mineralocorticoid 24-hour urinary aldosterone level or excess states | 24-hour urinary aldosterone level or specific measurements of other mineralocorticoids |
| Renovascular hypertension | Doppler flow study; magnetic resonance angiography |
| Sleep apnea | Sleep study with O2 saturation |
| Thyroid/ Parathyroid disease | TSH; serum PTH |
2013 ESH/ESC Guidelines For The Management of Arterial Hypertension (DO NOT EDIT)[2]
Search for Asymptomatic Kidney Diseases (DO NOT EDIT)[2]
| Class I |
| "1. Measurement of serum creatinine and estimation of GFR is recommended in all hypertensive patients. (Level of Evidence: B)" |
| "2. Assessment of urinary protein is recommended in all hypertensive patients by dipstick. (Level of Evidence: B)" |
| "3. Assessment of microalbuminuria is recommended in spot urine and related to urinary creatinine excretion. (Level of Evidence: B)" |
References
- ↑ Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL; et al. (2003). "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report". JAMA. 289 (19): 2560–72. doi:10.1001/jama.289.19.2560. PMID 12748199.
- ↑ 2.0 2.1 Authors/Task Force Members. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A; et al. (2013). "2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)". Eur Heart J. 34 (28): 2159–219. doi:10.1093/eurheartj/eht151. PMID 23771844.