Aortic dissection causes

	Aortic dissection Microchapters
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Differentiating Aortic dissection from other Diseases
Epidemiology and Demographics
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Diagnostic Study of Choice
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Case Studies
Case #1
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vendhan Ramanujam M.B.B.S [2]

Overview

Atherosclerosis and hypertension are associated with spontaneous aortic dissection, while blunt trauma and sudden deceleration in a motor vehicle accident are major causes of traumatic aortic dissection.

Causes

Life Threatening Causes

Aortic dissection is a life threatening condition and must be treated as such irrespective of the causes. Life threatening conditions can result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular	Atherosclerosis, bicuspid aortic valve, hypertension, malignant hypertension, vasculitis
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Methonium
Ear Nose Throat	No underlying causes
Endocrine	Cushing's syndrome
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Aneurysms osteoarthritis syndrome, annuloaortic ectasia, bicuspid aortic valve, Ehlers-Danlos syndrome, Erdheim's cystic medial necrosis, familial aortic dissection, fibromuscular dysplasia, Loeys-Dietz syndrome, Marfan syndrome, mutation of TGF-β receptor genes, mutations in genes encoding α-actin and β-myosin, mutations in SMAD3, mutations in the gene encoding filamin A, Noonan syndrome, osteogenesis imperfecta, pseudoxanthoma elasticum, Turner syndrome
Hematologic	No underlying causes
Iatrogenic	Aortic valve replacement surgery, cardiac catheterization, coronary artery bypass graft surgery, implantation of stent graft, intra-aortic balloon pump, mitral valve replacement surgery, surgical correction of aortic coarctation
Infectious Disease	AIDS, annuloaortic ectasia, aortitis, syphilitic aortitis
Musculoskeletal/Orthopedic	Ehlers-Danlos syndrome, osteogenesis imperfecta
Neurologic	No underlying causes
Nutritional/Metabolic	Homocystinuria
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Cocaine abuse
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Polycystic kidney disease
Rheumatology/Immunology/Allergy	Aortitis, arteritis, Behçet's disease, giant cell arteritis, rheumatoid arthritis, scleroderma, systemic lupus erythematosus, Takayasu arteritis, vasculitis
Sexual	No underlying causes
Trauma	Chest trauma, deceleration injuries, motor vehicle accident
Urologic	No underlying causes
Miscellaneous	Connective tissue disorders, heavy exercise, idiopathic

Causes in Alphabetical Order

References

↑ "Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group". Ophthalmology. 98 (5 Suppl): 807–22. 1991. PMID 2062514.
↑ Shen, YZ.; Song, W.; Lu, HZ. (2012). "Type I aortic dissection in a patient with human immunodeficiency virus infection". Biosci Trends. 6 (3): 143–6. PMID 22890163. Unknown parameter |month= ignored (help)
↑ Mohr, FW.; Falk, V.; Diegeler, A.; Walther, T.; van Son, JA.; Autschbach, R. (1998). "Minimally invasive port-access mitral valve surgery". J Thorac Cardiovasc Surg. 115 (3): 567–74, discussion 574-6. PMID 9535444. Unknown parameter |month= ignored (help)
↑ Arbustini, E.; Narula, N. (2012). "Extra-aortic identifiers to guide genetic testing in familial thoracic aortic aneurysms and dissections syndromes: it is all about the company one keeps". J Am Coll Cardiol. 60 (5): 404–7. doi:10.1016/j.jacc.2012.03.032. PMID 22633652. Unknown parameter |month= ignored (help)
↑ Angouras, DC.; Michler, RE. (2002). "An alternative surgical approach to facilitate minimally invasive mitral valve surgery". Ann Thorac Surg. 73 (2): 673–4. PMID 11845906. Unknown parameter |month= ignored (help)
↑ "GANGLION-BLOCKING drugs and dissection of the aorta". Br Med J. 1 (4981): 1473–4. 1956. PMID 13316190. Unknown parameter |month= ignored (help)
↑ ^7.0 ^7.1 ^7.2 ^7.3 Choi, JC.; LeMaire, SA. (2012). "Thoracic aortic dissection: genes, molecules, and the knife". Tex Heart Inst J. 39 (6): 838–9. PMID 23304027.
↑ Gignon, M.; Defouilloy, C.; Montpellier, D.; Chatelain, D.; Traulle, S.; Ammirati, C.; Jarde, O.; Manaouil, C. (2011). "Sudden death caused by aortic dissection in a patient with polycystic kidney disease". Genet Couns. 22 (4): 333–9. PMID 22303792.

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[pmid2062514-1] "Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group". Ophthalmology. 98 (5 Suppl): 807–22. 1991. PMID 2062514.

[Shen-2012-2] Shen, YZ.; Song, W.; Lu, HZ. (2012). "Type I aortic dissection in a patient with human immunodeficiency virus infection". Biosci Trends. 6 (3): 143–6. PMID 22890163. Unknown parameter |month= ignored (help)

[Mohr-1998-3] Mohr, FW.; Falk, V.; Diegeler, A.; Walther, T.; van Son, JA.; Autschbach, R. (1998). "Minimally invasive port-access mitral valve surgery". J Thorac Cardiovasc Surg. 115 (3): 567–74, discussion 574-6. PMID 9535444. Unknown parameter |month= ignored (help)

[Arbustini-2012-4] Arbustini, E.; Narula, N. (2012). "Extra-aortic identifiers to guide genetic testing in familial thoracic aortic aneurysms and dissections syndromes: it is all about the company one keeps". J Am Coll Cardiol. 60 (5): 404–7. doi:10.1016/j.jacc.2012.03.032. PMID 22633652. Unknown parameter |month= ignored (help)

[Angouras-2002-5] Angouras, DC.; Michler, RE. (2002). "An alternative surgical approach to facilitate minimally invasive mitral valve surgery". Ann Thorac Surg. 73 (2): 673–4. PMID 11845906. Unknown parameter |month= ignored (help)

[-1956-6] "GANGLION-BLOCKING drugs and dissection of the aorta". Br Med J. 1 (4981): 1473–4. 1956. PMID 13316190. Unknown parameter |month= ignored (help)

[Choi-2012-7] 7.0 ^7.1 ^7.2 ^7.3 Choi, JC.; LeMaire, SA. (2012). "Thoracic aortic dissection: genes, molecules, and the knife". Tex Heart Inst J. 39 (6): 838–9. PMID 23304027.

[Gignon-2011-8] Gignon, M.; Defouilloy, C.; Montpellier, D.; Chatelain, D.; Traulle, S.; Ammirati, C.; Jarde, O.; Manaouil, C. (2011). "Sudden death caused by aortic dissection in a patient with polycystic kidney disease". Genet Couns. 22 (4): 333–9. PMID 22303792.

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