Leopard syndrome differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Differentiating Leopard Syndrome from other Diseases

• McCune-Albright syndrome:

It is suspected when two of the three following features are present:

1. Endocrine(autonomous)hyperfunction such as precocious puberty,
2. Fibrous dysplasia
3. Café-au-lait spots

Within the syndrome there are bone fractures and deformity of the legs, arms and skull, different pigment patches on the skin, and early puberty with increased rate of growth.

• Carney syndrome:

coexistence of several neoplasms, including: gastric epithelioid leiomyosarcoma, pulmonary chondroma, and extra-adrenal paraganglioma

• Lentigo
• Neurofibromatosis