Lipoprotein disorders historical perspective
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Lipoprotein Disorders Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
From the early 1950s onward, Fredrickson specialized in the study of plasma lipoproteins, compounds of proteins and lipids which transport lipids in the blood. However, the study of lipids in the blood has started early in the 1900's. In 1949, Faraday Society in Birmingham organized the first symposium on lipoproteins and seperated for the first time lipoproteins into alpha and beta types. More progress on the understanding of the nature and function of lipoprotein continued throughout the years, and in 1970 Fredrickson classified the lipids in the blood as different types of lipoproteins in the famous "Fredrickson classification" which shifted the traditional name of hyperlipidemia into hyperlipoproteinemia. Since then, more and more studies were conducted on lipoproteins which lead to the discovery of lipoprotein receptors, enzymes and genes and the association between the levels of specific lipoprotein levels and cardiovascular risks and mortality.